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The administration of GLP-1RA exendin-4 restored microglial homeostasis, reduced cytokine secretion, and limited astrocyte activation, especially of the A1 phenotype, as well as reduced neuronal apoptosis

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C., Clegg, D

Notably, treatment with APR-017 alone affected neither ROS level nor cell viability, while treatment with IC261 alone slightly elevated ROS level and reduced cell viability